PUBLICATIONS - 2024

53. SUPRAMOLECULAR HETERODIMER PEPTIDES ASSEMBLY FOR NANOPARTICLES FUNCTIONALIZATION

Mathieu C†, Ghosh S†, Draussin J, Gasser A, Jacquot G, Banerjee M, Gupta T, Schmutz M, Mirjolet C, Tillement O, Lux F, Klymchenko A, Donzeau M, Pivot X, Harlepp S, Detappe A*. Adv Healthc Mater 2024

PUBLICATIONS - 2023

52. SITE-SELECTIVE PROTEIN CONJUGATION BY A MULTICOMPONENT UGI REACTION

Koutsopetras I, Vaur V, Benazza R, Diemer H, Sornay C, Ersoy Y, Rochet L, Longo C, Hernandez-Alba O, Erb S, Detappe A, Skerra A, Wagner A, Cianferani S, Chaubet G*. Chem. Eur. J. 2023

Screenshot 2024-03-28 at 13.09_edited.jp

51. SUBCUTANEOUS ADMINISTRATION OF A ZWITTERIONIC CHITOSAN-BASED HYDROGEL FOR CONTROLLED SPATIOTEMPORAL RELEASE OF MONOCLONAL ANTIBODIES

Gréa T, Jacquot G, Durand A, Mathieu C, Gasser A, Zhu C, Banerjee M, Hucteau E, Mallard J, Popescu BV, Thomas E, Kryza D, Sidi-Boumedine J, Ferrauto G, Gianolio E, Fleith G, Combet J, Brun S, Erb S, Cianferani S, Charbonnière LJ, Fellmann L, Mirjolet C, David L, Tillement O, Lux F, Harlepp S, Pivot X, Detappe A*. Adv Mater 2023

50. CLINICAL VALIDATION OF PNEUMATIC TRANSPORTATION SYSTEMS FOR MONOCLONAL ANTIBODIES

Coliat P, Erb S, Diemer H, Karouby D, Banerjee M, Zhu C, Demarchi M, Cianferani S, Detappe A, Pivot X*, Sci. Rep. 2023

49. AN AUTOINHIBITED STATE OF 53BP1 REVEALED BY SMALL MOLECULE ANTAGONISTS AND PROTEIN ENGINEERING

Cui G, Botuyan MV, Drane P, Hu Q, Bragantini B, Thompson JR, Schuller DJ, Detappe A, Perfetti MT, James LI, Frye SV, Chowdhury D*, Mer G*. Nat Commun 2023

48. TOWARD CLINICAL TRANSFER OF TUMOR-TARGETED ULTRASMALL INORGANIC NANOPARTICLES

Carmès L†, Banerjee M†, Coliat P, Harlepp S, Pivot X, Tillement O, Lux F, Detappe A*. Adv Therapeutics 2023

47. MOLECULAR BOTTLEBRUSH PRODRUGS AS NEXT-GENERATION MONO AND TRIPLEX COMBINATION THERAPIES FOR MULTIPLE MYELOMA

Detappe A†, Nguyen HVTN†, Jiang Y, Agius MP, Wang W, Mathieu C, Su NK, Kristufek SL, Lundberg DJ, Bhagchandani S, Ghobrial IM*, Ghoroghchian PP*, Johnson JA*. Nat Nanotech 2023

- Nature Nanotechnology News&Views: https://www.nature.com/articles/s41565-022-01265-3

- MIT News: https://news.mit.edu/2023/targeting-cancer-multidrug-nanoparticle-0126

- Science China Materials: https://link.springer.com/article/10.1007/s40843-023-2482-8

46. CLINICALLY TRANSATABLE TRANSCROCETIN DELIVERY PLATFORM FOR CORRECTION OF TUMOR HYPOXIA AND ENHANCEMENT OF RADIATION THERAPY EFFECTS
Diringer MC, Coliat P, Mathieu C, Laurent N, Mura C, Banerjee M, Zhu C, Grabowska A, Ritchie A, Clarke P, Bernard A, Vit C, Burckel H, Noel G, Harvey P, Pivot X, Detappe A*. Small 2023

PUBLICATIONS - 2022

45. A COMBINATION OF NATIVE LC-MS APPROACHES FOR THE COMPREHENSIVE CHARACTERIZATION OF THE ANTIBODY-DRUG CONJUGATE TRASTUZUMAB-DERUXTECAN
Desligniere E, Diemer H, Erb S, Coliat P, Pivot X, Detappe A, Hernandez-Alba O, Cianferani S*. Front Biosci 2022.

44. LEAF- 4L6715 ENHANCES OXYGENATION IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) DUE TO SEVERE COVID-19: FINAL RESULTS OF A PHASE I/II CLINICAL TRIAL

Mertes PM, Delabranche X, Coliat P, Roche A, Collange O, Voegelin M, Bernard A, Dhindsa N, Xu ZH, Geng B, Niyikiza C, Moyo V, Bourban C, Villa P, Detappe A*, Pivot X*. MedRxiv 2022

43. OPTIMAL PHYSICOCHEMICAL PROPERTIES OF ANTIBODY-NANOPARTICLE CONJUGATES FOR IMPROVED TUMOR TARGETING

Mittelheisser V, Coliat P, Moeglin E, Goepp L, Goetz JG, Charbonnière LJ, Pivot X, Detappe A*. Adv Mat. 2022

- CNRS press release: https://www.alsace.cnrs.fr/fr/cnrsinfo/cancer-et-chimiotherapie-ciblee-trois-questions-alexandre-detappe-et-vincent-mittelheisser

- University of Strasbourg press release: https://crbs.unistra.fr/actualites/actualite/mieux-cibler-tumeurs-cancereuses-nanoparticules-specifiques-encapsulant-anticorps-therapeutiques

PUBLICATIONS - 2021

42. ANTI-BCMA IMMUNO-NANOPET RADIOTRACERS FOR IMPROVED DETECTION OF MULTIPLE MYELOMA

Thomas E, Mathieu C, Moreno-Gaona P, Mittelheisser V, Lux F, Tillement O, Pivot X, Ghoroghchian PP, Detappe A*. Adv Healthc Mater. 2021

41. TROIKA-1: A DOUBLE-BLIND, RANDOMIZED, PARALLEL GROUP, STUDY AIMED TO DEMONSTRATE THE EQUIVALENT PHARMACOKINETIC PROFILE OF HD201, A POTENTIAL BIOSIMILAR CANDIDATE TO TRASTUZUMAB, VERSUS EU-HERCEPTIN AND US-HERCEPTIN IN HEALTHY MALE SUBJECTS

Demarchi M, Coliat P, Mclendon K, Hi JCS, Feyaerts P, Ang F, Jaison L, Deforce F, Derde MP, Kim MJ, Park LS, Detappe A, Pivot X*. Pharmacol Res Perspect. 2021

40. LIPOSOMAL ENCAPSULATION OF TRANS-CROCETIN ENHANCES OXYGENATION IN PATIENTS WITH COVID-19-RELATED ARDS RECEIVING MECHANICAL VENTILATION

Mertes PM, Olivier Collange O, Coliat P, Banerjee M, Diringer MC, Roche A, Delabranche X, Chaban V, Voegelin M, Bernard A, Sartori V, Laurent N, Velten M, Dhindsa N, Defuria J, Kim G, Xu ZH, Theodorou M, Huang ZR, Khalifa K, Geng B, Niyikiza C, Moyo V, Gizzi P, Villa P, Detappe A*, Xavier Pivot X*. J Control Release 2021

39. RAL GTPASES PROMOTES BREAST CANCER METASTASES BY CONTROLLING BIOGENESIS AND ORGAN TARGETING OF EXOSOMES

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud J, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V. Elife 2021

PUBLICATIONS - 2020

38. LEVERAGING IMMUNOTHERAPY WITH NANOMEDICINE.

Mittelheisser V, Banerjee M, Pivot X, Charbonnière L, Goetz J, Detappe A*. Adv Ther. 2020

37. RETROSPECTIVE EVALUATION OF WHOLE EXOME AND GENOME MUTATION CALLS IN 746 CANCER SAMPLES.

Bailey MH, Meyerson WU, Dursi LJ, Wang LB, Dong G, Liang WW, Weerasinghe A, Li S, Kelso S; MC3 Working Group; PCAWG novel somatic mutation calling methods working group, Saksena G, Ellrott K, Wendl MC, Wheeler DA, Getz G, Simpson JT, Gerstein MB, Ding L; PCAWG Consortium. Nat Commun 2020

36. PRO-ORGANIC RADICAL CONTRAST AGENTS (“PRO-ORCAS”) FOR REAL-TIME MRI OF PRO-DRUG ACTIVATION IN BIOLOGICAL SYSTEMS.

Nguyen HVTN†, Detappe A†, Harvey P, Gallagher N, Mathieu C, Agius MP, Zavidij O, Wang W, Jiang J, Rajca A, Jasanoff A, Ghobrial IM, Ghoroghchian PP*, Johnson JAJ*. Polym Chem. 2020

35. NON-INVASIVE IMAGING OF TUMOR HYPOXIA AFTER NANOPARTICLE-MEDIATED TUMOR VASCULAR DISRUPTION.

Virani NA, Kelada OJ, Kunjachan S, Detappe A, Kwon J, Hayashi J, Vasquez-Pagan A, Biancur DE, Ireland T, Kumar R, Sridhar S, Makrigiorgos GM, Berbeco RI*. Plos One. 2020

34. ANTI-MUC1-C ANTIBODY-CONJUGATED NANOPARTICLES POTENTIATE THE EFFICACY OF FRACTIONATED RADIATION THERAPY.

Detappe A*, Mathieu C, Jin C, Agius MP, Diringer MC, Tran VL, Pivot X, Lux F, Tillement O, Kufe D*, Ghoroghchian PP*. Int J Radiat Oncol Biol Phys. 2020

33. PAN-CANCER ANALYSIS OF WHOLE GENOMES.

ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature. 2020

PUBLICATIONS - 2019

32. ANTIBODY-TARGETING OF ULTRA-SMALL NANOPARTICLES ENHANCES IMAGING SENSITIVITY AND ENABLES LONGITUDINAL TRACKING OF MULTIPLE MYELOMA.

Detappe A, Reidy M, Yu Y, Mathieu C, Nguyen HV, Coroller TP, Lam F, Jarolim P, Harvey P, Protti A, Nguyen QD, Johnson JA, Cremillieux Y, Tillement O, Ghobrial IM*, Ghoroghchian PP*. Nanoscale. 2019

31. FLUORESCENCE MONITORING OF RARE CIRCULATING TUMOR CELL AND CLUSTER DISSEMINATION IN A MULTIPLE MYELOMA XENOGRAFT MODEL IN VIVO.

Patil R, Tan X, Bartosik P, Detappe A, Runnels JM, Ghobrial IM, Lin CP, Niedre M*, J Biomed Opt. 2019

30. MITOCHONDRIAL METABOLISM PROMOTES ADAPTATION TO PROTEOTOXIC STRESS.

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR. Nat Chem Biol 2019

29. SELECTIVE PRIMING OF TUMOR BLOOD VESSELS BY RADIATION THERAPY ENHANCES NANODRUG DELIVERY.

Kunjachan S, Kotb S, Pola R, Pechar M, Kumar R, Singh B, Gremse F, Taleeli R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Yasmin-Karim S, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco RI. Sci Rep. 2019

28. AGUIX® FROM BENCH TO BEDSIDE-TRANSFER OF AN ULTRASMALL THERANOSTIC GADOLINIUM-BASED NANOPARTICLE TO CLINICAL MEDICINE

Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Sidi-Boumedine J, Janier M, Butterworth K, McMahon S, Prise K, Aloy MT, Ardail D, Rodriguez-Lafrasse C, Porcel E, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, Le Duc G, Tillement O. Br J Radiol. 2019

PUBLICATIONS - 2018

27. DYNLL1 BINDS TO MRE11 TO LIMIT DNA END RESECTION IN BRCA1-DEFICIENT CELLS

He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D. Nature. 2018

26. TRIPLY LOADED NITROXIDE BRUSH-ARM STAR POLYMERS ENABLE METAL-FREE MILLIMETRIC TUMOR DETECTION BY MAGNETIC RESONANCE IMAGING

Nguyen HV*, Detappe A*, Gallagher NM, Zhang H, Harvey P, Yan C, Mathieu C, Golder MR, Jiang Y, Ottaviani MF, Jasanoff A, Rajca A, Ghobrial I, Ghoroghchian PP, Johnson JA. ACS Nano. 2018. *equal contribution

25. MECHANISM OF 53BP1 ACTIVITY REGULATION BY RNA-BINDING TIRR AND A DESIGNER PROTEIN

Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G. Nat Struct Mol Biol. 2018

24. ADVANCEMENTS IN NANOMEDICINE FOR MULTIPLE MYELOMA

Detappe A, Bustoros M, Mouhieddine TH, Ghoroghchian PP. Trends Mol Med. 2018

23. ANTIBODY-DEPENDENT CELLULAR PHAGOCYTOSIS BY MACROPHAGES IS A NOVEL MECHANISM OF ACTION OF ELOTUZUMAB

Kurdi AT, Glavey SV, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM. Mol Cancer Ther. 2018

22. MULTIFACETED IMPACT OF MICRORNA 493-5P ON GENOME-STABILIZING PATHWAYS INDUCES PLATINUM AND PARP INHIBITOR RESISTANCE IN BRCA2-MUTATED CARCINOMAS

Meghani K, Fuchs W, Detappe A, Drané P, Gogola E, Rottenberg S, Jonkers J, Matulonis U, Swisher EM, Konstantinopoulos PA, Chowdhury D. Cell Rep. 2018

21. DIFFERENCES IN NANOPARTICLE UPTAKE IN TRANSPLANTED AND AUTOCHTHONOUS MODELS OF PANCREATIC CANCER

Tao Z, Muzumdar MD, Detappe A, Huang X, Xu ES, Yu Y, Mouhieddine TH, Song H, Jacks T, Ghoroghchian PP. Nano Lett. 2018

20. THE BONE-MARROW NICHE IN MDS AND MGUS: IMPLICATIONS FOR AML AND MM

Ghobrial IM, Detappe A, Anderson KC, Steensma DP. Nat Rev Clin Oncol. 2018

PUBLICATIONS - 2017

19. NANOPARTICLE CONJUGATES OF A HIGHLY POTENT TOXIN ENHANCE SAFETY AND CIRCUMVENT PLATINUM RESISTANCE IN OVARIAN CANCER

Qi R, Wang Y, Bruno PM, Xiao H, Yu Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Huang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP. Nat Commun. 2017

18. NIR-EMISSIVE PEG-B-TCL MICELLES FOR BREAST TUMOR IMAGING AND MINIMALLY INVASIVE PHARMACOKINETIC ANALYSIS

Hofmann CL, O'Sullivan MC, Detappe A, Yu Y, Yang X, Qi W, Landon CD, Therien MJ, Dewhirst MW, Ghoroghchian PP, Palmer GM. Nanoscale. 2017

17. ESTABLISHED AND NOVEL PROGNOSTIC BIOMARKERS IN MULTIPLE MYELOMA

Bustoros M, Mouhieddine TH, Detappe A, Ghobrial IM. Am Soc Clin Oncol Educ Book. 2017

16. THE MUTATIONAL LANDSCAPE OF CIRCULATING TUMOR CELLS IN MULTIPLE MYELOMA

Mishima Y, Paiva B, Shi J, Park J, Manier S, Takagi S, Massoud M, Perilla-Glen A, Aljawai Y, Huynh D, Roccaro AM, Sacco A, Capelletti M, Detappe A, Alignani D, Anderson KC, Munshi NC, Prosper F, Lohr JG, Ha G, Freeman SS, Van Allen EM, Adalsteinsson VA, Michor F, San Miguel JF, Ghobrial IM. Cell Rep. 2017

15. TIRR REGULATES 53BP1 BY MASKING ITS HISTONE METHYL-LYSINE BINDING FUNCTION

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D. Nature. 2017

14. ULTRASMALL SILICA-BASED BISMUTH GADOLINIUM NANOPARTICLES FOR DUAL MAGNETIC RESONANCE-COMPUTED TOMOGRAPHY IMAGE GUIDED RADIATION THERAPY

Detappe A, Thomas E, Tibbitt MW, Kunjachan S, Zavidij O, Parnandi N, Reznichenko E, Lux F, Tillement O, Berbeco R. Nano Lett. 2017

PUBLICATIONS - 2016

13. KEY CLINICAL BEAM PARAMETERS FOR NANOPARTICLE-MEDIATED RADIATION DOSE AMPLIFICATION

Detappe A, Kunjachan S, Drané P, Kotb S, Myronakis M, Biancur DE, Ireland T, Wagar M, Lux F, Tillement O, Berbeco R. Sci Rep. 2016

12. ADVANCED MULTIMODAL NANOPARTICLES DELAY TUMOR PROGRESSION WITH CLINICAL RADIATION THERAPY

Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Biancur D, Drane P, Guieze R, Makrigiorgos GM, Tillement O, Langer R, Berbeco R. J Control Release. 2016

11. STEREOTACTIC MODULATION OF BLOOD-BRAIN BARRIER PERMEABILITY TO ENHANCE DRUG DELIVERY

Appelboom G, Detappe A, LoPresti M, Kunjachan S, Mitrasinovic S, Goldman S, Chang SD, Tillement O. Neuro Oncol. 2016

10. PUSHING RADIATION THERAPY LIMITATIONS WITH THERANOSTIC NANOPARTICLES

Detappe A, Lux F, Tillement O. Nanomedicine (Lond). 2016

9. GADOLINIUM-BASED NANOPARTICLES AND RADIATION THERAPY FOR MULTIPLE BRAIN MELANOMA METASTASES: PROOF OF CONCEPT BEFORE PHASE I TRIAL

Kotb S, Detappe A, Lux F, Appaix F, Barbier EL, Tran VL, Plissonneau M, Gehan H, Lefranc F, Rodriguez-Lafrasse C, Verry C, Berbeco R, Tillement O, Sancey L. Theranostics. 2016

8. FOCUSED ULTRASOUND TO TRANSIENTLY DISRUPT THE BLOOD BRAIN BARRIER

Mitrasinovic S, Appelboom G, Detappe A, Sander Connolly E Jr. J Clin Neurosci. 2016

7. LOW Z TARGET SWITCHING TO INCREASE TUMOR ENDOTHELIAL CELL DOSE ENHANCEMENT DURING GOLD NANOPARTICLE-AIDED RADIATION THERAPY

Berbeco RI, Detappe A, Tsiamas P, Parsons D, Yewondwossen M, Robar J. Med Phys. 2016

PUBLICATIONS PRIOR 2016

6. NANOPARTICLE MEDIATED TUMOR VASCULAR DISRUPTION: A NOVEL STRATEGY IN RADIATION THERAPY

Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI. Nano Lett. 2015

5. AGUIX NANOPARTICLES AS A PROMISING PLATFORM FOR IMAGE-GUIDED RADIATION THERAPY

Detappe A, Kunjachan S, Rottmann J, Robar J, Tsiamas P, Korideck H, Tillement O, Berbeco R. Cancer Nanotechnol. 2015

4. [ULTRASMALL NANOPARTICLES FOR RADIOTHERAPY: AGUIX]

Lux F, Detappe A, Dufort S, Sancey L, Louis C, Carme S, Tillement O. Cancer Radiother. 2015

3. NEW POTENTIAL FOR ENHANCING CONCOMITANT CHEMORADIOTHERAPY WITH FDA APPROVED CONCENTRATIONS OF CISPLATIN VIA THE PHOTOELECTRIC EFFECT

Altundal Y, Cifter G, Detappe A, Sajo E, Tsiamas P, Zygmanski P, Berbeco R, Cormack RA, Makrigiorgos M, Ngwa W. Phys Med. 2015

2. THE USE OF THERANOSTIC GADOLINIUM-BASED NANOPROBES TO IMPROVE RADIOTHERAPY EFFICACY

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Crémillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O. Br J Radiol. 2014

1. THE EFFECT OF FLATTENING FILTER FREE DELIVERY ON ENDOTHELIAL DOSE ENHANCEMENT WITH GOLD NANOPARTICLES

Detappe A, Tsiamas P, Ngwa W, Zygmanski P, Makrigiorgos M, Berbeco R. Med Phys. 2013