Publications.

Detappe A†, Gutierrez-Blanco M, Pivot X†. “Engineering the subcutaneous delivery of antibody-drug conjugates”. J Control Release, 2026

Tillement A, Nemeth E, David L, Cenesiz D, Neumayer U, Fousse M, Liu Y, Schultz-Schaeffer, Fassbender K, Detappe A, Lux F, Groppa S, Tillement O, Decker Y. “Artificial intelligence decodes brain elemental signatures to stratify neurological aging”. Research, 2026

Detappe A†, André F. “Dynamic precision for cancer nanomedicine”. Nat Rev Bioeng, 2025

Thibaudeau C, Bour C, Sarpi-Luttenauer M, Mesdom P, Karges J, Gandioso A, Zhou L, Harlepp S, Detappe A, Burgy M, Martin S, Mellitzer G, Gaiddon C, Gasser G, Jung AC†. “Inverse correlation between endoplasmic reticulum stress intensity and antitumor immune response with ruthenium(II)-based photosensitizers for the photodynamic therapy of head and neck squamous cell carcinoma.”. J Med Chem, 2025

Jung S, Lopez Navarro P, Gasser A, Bou-Gharios J, Donzeau M, Mirjolet C, Noel G, Schmitt JL, Pivot X, Harlepp S, Detappe A†. “A modular supramolecular peptide platform reveals atomic-number-dependent mechanisms driving radioenhancement”. ACS Nano, 2025

Mittelheisser V, Lefebvre O, Banerjee M, Soltany R, Ghosh S, Dupas A, Diringer MC, Blumberger J, Bochler L, Harlepp S, Larnicol A, Pichot A, Stemmelen T, Molitor A, Rompai M, Carapito C, Carapito R, Menard-Moyon C, Bianco A, Charbonnière LJ, Lux F, Tillement O, Goetz JG†, Detappe A†. “Nanomaterials trigger functional anti-tumoral responses in primary human cells”. Adv Sci, 2025 (featured in the inside front cover of the issue)

Bovone G, Bernhard S, Jacquot G, Mittelheisser V, Mirjolet C, Guzzi EA, Garau Paganella L, Liebi L, Lefebvre O, Goetz J, Charbonnière LJ, Pivot X, Harlepp S, Tibbitt MW†, Detappe A†. “Reinforced polymer-nanoparticle hydrogels for subcutaneous and sustained delivery of trastuzumab”. Adv Health Mater, 2025

Durand A*, Gréa T*, Lebeau G, Jacquot G, Tillement A, Aigle A, Thomas E, Kryza D, Taleb J, Ferrauto G, Gianolio E, Géloen A, Montembault A, Gutierrez-Blanco M, Pivot X, Harlepp S, Detappe A, David L†, Lux F†, Tillement O†. “Functionalization of chitosan with polycarboxylic macrocycle yields injectable hydrogel with pH and salts responsiveness”. Mater Today Adv, 2025.

Los Angeles Ramirez M, Bou-Gharios J, Freis B, Draussin J, Cheignon C, Charbonnière LJ, Laurent S, Gevart T, Gasser A, Jung S, Rossetti F, Tillement O, Noel G, Pivot X, Detappe A†, Bégin-Colin S†, Harlepp S†. “Spacer engineering in nanoparticle-peptide conjugates boosts targeting specificity for tumor-associated antigens”. Nanoscale, 2025 (featured in the inside front cover of the issue)

Boos A, Most J, Cahuzac H, Moreira da Silva L, Daubeuf F, Erb S, Cianferani S, Hernandez-Alba O, Semenchenko C, Dovgan I, Kolodych S, Detappe A, Dantzer F, Wagner A, Zeniou M†, Chaubet G†. “Antibody-Vincristine Conjugates as Potent Anti-Cancer Agents”. J Med Chem, 2024.

Jacquot G, Lopez Navarro P, Grange C, Boudali L, Harlepp S, Pivot X, Detappe A†. “Landscape of subcutaneous administration strategies for monoclonal antibodies in oncology”. Adv Mat, 2024 (featured in the cover of the issue)

Vaur V, Koutsopetras I, Erb S, Jackowska B, Benazza R, Cahuzac H, Detappe A, Hernandez-Alba O, Cianférani S, Scott CJ, Chaubet G†. Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction. Chembiochem, 2024

Mathieu C*, Ghosh S*, Draussin J, Gasser A, Jacquot G, Banerjee M, Gupta T, Schmutz M, Mirjolet C, Tillement O, Lux F, Klymchenko A, Donzeau M, Pivot X, Harlepp S, Detappe A†. “Supramolecular heterodimer peptides assembly for nanoparticles functionalization”. Adv Healthc Mater, 2024 (featured in the cover of the issue)

Koutsopetras I*, Vaur V*, Benazzia R, Diemer H, Sornay C, Ersoy Y, Rochet L, Longo C, Hernandez OA, Erb S, Detappe A, Skerra A, Wagner A, Cianferani S, Chaubet G†. “Site-selective protein conjugation by a multicomponent Ugi reaction”. Chem Eur J, 2023

Grea T*, Jacquot G*, Durand A, Mathieu C, Gasser A, Zhu C, Banerjee M, Hucteau E, Mallard J, Brichard T, Thomas E, Ferrauto G, Gianolio E, Fleith G, Combet J, Braun S, Erb S, Cianferani S, Charbonniere LJ, Mirjolet C, David L, Harlepp S, Tillement O, Lux F, Pivot X, Detappe A†. “Zwitterionic chitosan-based hydrogel formulation for subcutaneous administration of monoclonal antibodies”. Adv Mat, 2023 (featured in the cover of the issue)

Cui G, Botuyan MV, Drané P, Hu Q, Bragantini B, Thompson JR, Schuller DJ, Detappe A, Perfetti MT, James LI, Frye SV, Chowdhury D, Mer G†. “An autoinhibited state of 53BP1 revealed small molecule antagonists and protein engineering”. Nat Commun, 2023

Lena C*, Banerjee M*, Coliat P, Harlepp S, Pivot X, Tillement O, Lux F†, Detappe A†. “Toward clinical transfer of tumor-targeted ultrasmall inorganic nanoparticles”. Adv Therapeutics, 2023 (featured in the cover of the issue)

Coliat P, Erb S, Diemer H, Karouby D, Banerjee M, Zhu C, Demarchi M, Cianferani S†, Detappe A†, Pivot X†. “Influence of pneumatic transportation on the stability of monoclonal antibodies”. Sci Rep, 2023

Diringer MC, Coliat P, Mathieu C, Laurent N, Zhu C, Mura C, Banerjee M, Grabowska A, Ritchie A, Clarke P, Bernard A, Vit C, Burckel H, Noel G, Harvey P, Pivot X, Detappe A†. “Clinically translatable transcrocetin delivery platform for correction of tumor hypoxia and enhancement of radiation therapy effects”. Small, 2023 Jan 1:e2205961 (featured in the cover of the issue)

Detappe A*, Nguyen HVTN*, Jiang Y, Agius P, Wang W, Mathieu C, Su NK, Kristufek SL, Lundberg DJ, Bhagchandani S, Ghobrial IM†, Ghoroghchian PP†, Johnson JA†. “Molecular bottlebrush prodrugs as next-generation mono and triplex combination therapies for multiple myeloma”. Nat Nanotechnol, 2023 Feb;18(2):184-192

Deslignière E, Diemer H, Erb S, Coliat P, Pivot X, Detappe A, Hernandez-Alba O, Cianferani S. “A combination of native LC-MS approaches for the comprehensive characterization of the site-specific antibody-drug conjugate trastuzumab deruxtecan”. Front Biosci, 2022 Oct 26;27(10):290 (featured in the cover of the issue)

Mertes PM, Delabranche X, Coliat P, Roche A, Collange O, Voegelin M, Bernard A, Dhindsa N, Xu ZH, Geng B, Niyikiza C, Moyo V, Bourban B, Villa P, Detappe A*,†, Pivot X*,†. “LEAF-4L6715 enhances oxygenation in patients with acute respiratory distress syndrome (ARDS) due to severe COVID-19: Final results of a phase I/II clinical trial”. MedRxiv, 2022.

Mittelheisser V, Coliat P, Moeglin E, Goepp, Goetz JG, Charbonnière LJ, Pivot X, Detappe A† “Optimal physicochemical properties of antibody-nanoparticle conjugates for improved tumor targeting”. Adv Mat, 2022 Jun;34(24):e2110305

Thomas E, Mathieu C, Lux F, Tillement O, Pivot X, Ghoroghchian PP†, Detappe A† “Anti-BCMA immune-nanoPET tracer for improved detection of Multiple Myeloma”. Adv Healthc Mater, 2021 Oct 28:e2101565.

Demarchi M, Coliat P, Mclendon K, Hi JCS, Feyaerts P, Ang F, Jaison L, Deforce F, Derde MP, Kim MJ, Park LS, Detappe A, Pivot X. “TROIKA-1: A Double-Blind, Randomized, Parallel Group, Study Aimed to Demonstrate the Equivalent Pharmacokinetic Profile of HD201, a Potential Biosimilar Candidate to Trastuzumab, Versus EU-Herceptin and US-Herceptin in Healthy Male Subjects”. Pharmacol Res Perspect, 2021;9:e00839

Mertes PM, Collange O, Coliat P, Banerjee M, Diringer MC, Roche A, Delabranche X, Chaban V, Voegelin M, Bernard A, Sartori V, Velten M, Dhindsa N, Defuria J, Gwangseong K, Xu H, Theodorou M, Huang R, Kalifa K, Geng B, Niyikiza C, Moyo V, Gizzi P, Villa P, Detappe A†,*, Pivot X†,* “Liposomal Encapsulation of Trans-crocetin Enhances Oxygenation in Patients with COVID-19-Related ARDS Receiving Mechanical Ventilation”. J Control Release, 2021, 336:252-261

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V “Ral GTPases promote metastases by controlling biogenesis and organ colonization of exosomes”. Elife, 2021, 10:e6539

Mittelheisser V, Banerjee M, Charbonnière LJ, Pivot X, Goetz J, Detappe A† ”Leveraging immunotherapy with nanomedicine”. Adv Therapeutics, 2020, 3(12):2000134

Detappe A†, Mathieu C, Jin C, Agius MP, Diringer MC, Tran VL, Pivot X, Lux F, Tillement O, Kufe D, Ghoroghchian PP†. “Anti-MUC1-C Antibody-conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy.”. Int J Radiat Oncol Biol Phys, 2020, 108(5):1380-1389

Detappe A*, Nguyen HVTN*, Harvey P, Gallagher N, Mathieu C, Agius MP, Zavidij O, Wang W, Jiang Y, Rajca A, Jasanoff A, Ghobrial IM, Ghoroghchian PP, Johnson JA “Pro-organic radical contrast agents for real-time MRI of pro-drug activation in biological systems.”. Polym Chem, 2020, 11, 4768-4779

Virani NA, Kelada OJ, Kunjachan S, Detappe A, Kwon J, Hayashi J, Vasquez-Pagan A, Biancur DE, Ireland T, Kumar R, Sridhar S, Makrigiorgos GM, Berbeco RI “Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption”. Plos One, 2020, 15(7):e0236245

Kunjachan S, Kotb S, Kumar R, Pola R, Pechar M, Gremse F, Taleei R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco R “Selective Vascular Modulation Improves Cancer Drug Delivery.”. Sci Rep, 2019, 9(1):15844

Detappe A, Reidy M, Yu Y, Mathieu C, Nguyen HVT, Coroller TP, Lam F, Jarolim P, Tillement O, Johnson JA, Ghoroghchian PP, Ghobrial IM “Antibody-targeted Gadolinium Nanoparticle Enhances Imaging Sensitivity and Enables Longitudinal Tracking of Multiple Myeloma.”. Nanoscale, 2019, 11(43):20485-20496

Patil R, Tan X, Bartosik P, Detappe A, Runnels J, Ghobrial I, Lin PC, Niedre M. “Fluorescence Monitoring of Rare Circulating Tumor Cell and Cluster Dissemination in a Multiple Myeloma Xenograft Model In Vivo.”. J Biomed Opt, 2019, 24(8):1-11

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Sanaagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR “Mitochondrial Metabolism Promotes Adaptation to Proteotoxic Stress”. Nat Chem Biol, 2019, 15(7):681-689

He YJ, Meghani K, Caron M-C, Yang C, Ronato DA, Bian J, Sharma A, Joshi N, Detappe A, Doench JG, Legube G, Root DE, D’Andrea AD, Drane P, De S, Konstantinopoulos P, Masson J-Y, Chowdhury D “DYNLL1 Inhibits NDA End Resection in BRCA1-deficient Cells and Regulates PARP inhibitor Sensitivity.”. Nature, 2018, 563(7732):522-526

Detappe A*, Nguyen HVTN*, Gallagher N, Zhang H, Harvey P, Yan C, Mathieu C, Golder MR, Jiang Y, Jasanoff A, Rajca A, Ghobrial IM, Ghoroghchian PP, Johnson JA “Triply Loaded Nitroxide Brush Arm Start Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging.”. ACS Nano, 2018, 12(11):11343-11354

Lux F, Tran V-LE, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Boschetti F, Angelovski G, Detappe A, Cremilleux Y, Mignet N, Doan B-T, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Muller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Janier M, Butterworth KT, McMahon SJ, Prise KM, Ardail D, Rodriguez-Lafrasse C, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, LeDuc G, Tillement O. “Review of AGuIX® ultrasmall theranostic nanoparticles: translation of a gadolinium based nanomedicine to the clinic.”. Br J Radiol, 2018, 18:20180365

Botuyan MV, Cui G, Drane P, Detappe A, Chaubey S, Bragantini B, Zhao D, Chowdhury D, Mer G “Mechanism of 53BP1 Activity Regulation by RNA-binding TIRR and a Designer Protein.”. Nat Struct Mol Biol, 2018, 25(7):591-600

Detappe A, Bustoros M, Mouhieddine TH, Ghoroghchian PP “Advancements in Nanomedicine for Multiple Myeloma.”. Trends Mol. Med, 2018, 24(6):560-574 (featured in the cover of the issue)

Kurdi A, Glavey S, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM. “Antibody Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab.”. Mol Cancer Ther, 2018, 17(7):1454-1463.

Meghani K, Fuchs W*, Detappe A*, Drane P, Gogola E, Rottenberg S, Jonkers J, Matulonis U, Swisher EM, Konstantinopoulos PA, Chowdhury D “Small RNA Sequencing Identifies mir-493-5p as a Novel Mediator of Platinum and PARP-inhibitor Resistance in BRCA2-mutated Ovarian Carcinoma.”. Cell Rep, 2018, 23(1):100-111.

Tao Z, Muzumdar MD, Detappe A, Huang X, Xu ES, Rong S, Xiao H, Yu Y, Mouhieddine TH, Song H, Jacks T, Ghoroghchian PP. “Optical Imaging Reveals Differences in Nanoparticle Uptake in Autochthonous and Xenograft Models of Pancreatic Cancer.”. Nano Lett, 2018, 18(4):2195-2208.

Ghobrial IM, Detappe A, Anderson KC, Steensma DP. “The Bone Marrow Niche in MDS and MGUS: Implication for Acute Myeloid Leukemia and Multiple Myeloma.”. Nat Rev Clin Oncol, 2018, 15(4):219-233.

Qi R, Wang Y, Bruno P, Xiao H, Yu Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP. “Nanoparticle-conjugates of a Highly Potent Toxin Enhance Safety and Circumvent Platinum Resistance in Ovarian Cancer.”. Nat Comm, 2017, 8(1):2166.

Hofmann CL, O'Sullivan MC, Detappe A, Yu Y, Yang X, Qi W, Landon CD, Therien MJ, Dewhirst MW, Ghoroghchian PP, Palmer GM. “NIR-emissive PEG-b-TCL Micelles for Breast Tumor Imaging and Minimally Invasive Pharmacokinetic Analysis.”. Nanoscale, 2017, 9(36):13465-13476.

Mishima Y, Paiva B, Shi J, Park J, Manier S, Takagi S, Massoud M, Perilla-Glen A, Aljawai Y, Huynh D, Roccaro AM, Sacco A, Capelletti M, Detappe A, Alignani D, Anderson KC, Munshi NC, Prosper F, Lohr JG, Ha G, Freeman SS, Van Allen EM, Adalsteinsson VA, Michor F, San Miguel JF, Ghobrial IM. “The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.”. Cell Rep, 2017, 19(1):218-224.

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D. “TIRR Regulates 53BP1 by Masking its Histone Methyl-lysine Binding Function.”. Nature, 2017, 543(7644):211-216.

Detappe A†, Thomas E, Tibbitt MW, Kunjachan S, Zavidij O, Parnandi N, Reznichenko E, Lux F, Tillement O, Berbeco R. “Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance-Computed Tomography Image Guided Radiation Therapy.”. Nano Lett, 2017 Mar 8;17(3):1733-1740.

Detappe A†, Kunjachan S, Drané P, Kotb S, Myronakis M, Biancur DE, Ireland T, Wagar M, Lux F, Tillement O, Berbeco R. “Key Clinical Beam Parameters for Nanoparticle-mediated Radiation Dose Amplification.”. Sci Rep, 2016, 6:34040.

Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Biancur D, Drane P, Guieze R, Makrigiorgos GM, Tillement O, Langer R, Berbeco R†. “Advanced Multimodal Nanoparticles Delay Tumor Progression With Clinical Radiation Therapy.”. J Control Release, 2016, 238:103-113.

Appelboom G†, Detappe A, LoPresti M, Kunjachan S, Mitrasinovic S, Goldman S, Chang SD, Tillement O. “Stereotactic Modulation of Blood Brain Barrier Permeability to Enhance Drug Delivery.”. Neuro Oncol, 2016, 18(12):1601-1609. (featured in the cover of the issue)

Kotb S, Detappe A, Lux F, Appaix F, Barbier EL, Tran VL, Plissonneau M, Gehan H, Lefranc F, Rodriguez-Lafrasse C, Verry C, Berbeco R, Tillement O, Sancey L†. “Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial.”. Theranostics, 2016, 6(3):418-27. (featured in the cover of the issue)

Detappe A†, Lux F, Tillement O†. “Pushing Radiation Therapy Limitations With Theranostic Nanoparticles.”. Nanomedicine (Lond), 2016, 11(9):997-9.

Mitrasinovic S, Appelboom G, Detappe A, Sander Connolly E Jr†. “Focused Ultrasound to Transiently Disrupt the Blood Brain Barrier.”. J Clin Neurosci, 2016, 28:187-9.

Berbeco RI†, Detappe A, Tsiamas P, Parsons D, Yewondwossen M, Robar J. “Low Z Target Switching to Increase Tumor Endothelial Cell Dose Enhancement During Gold Nanoparticle-aided Radiation Therapy.”. Med Phys, 2016, 43(1):436.

Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI†. “Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.”. Nano Lett, 2015, 15(11):7488-96.

Detappe A, Kunjachan S, Rottmann J, Robar J, Tsiamas P, Korideck H, Tillement O, Berbeco R†. “AGuIX Nanoparticles as a Promising Platform for Image-guided Radiation Therapy.”. Cancer Nanotechnol, 2015, 6(1):4.

Lux F, Detappe A, Dufort S, Sancey L, Louis C, Carme S, Tillement O†. “[Ultrasmall Nanoparticles for Radiotherapy: AGuIX]”. Cancer Radiother, 2015, 19(6-7):508-14.

Altundal Y, Cifter G, Detappe A, Sajo E, Tsiamas P, Zygmanski P, Berbeco R, Cormack RA, Makrigiorgos M, Ngwa W†. “New Potential for Enhancing Concomitant Chemoradiotherapy with FDA Approved Concentrations of Cisplatin via the Photoelectric Effect.”. Phys Med, 2015, 31(1):25-30.

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Crémillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O†. “The Use of Theranostic Gadolinium-based Nanoprobes to Improve Radiotherapy Efficacy.”. Br J Radiol, 2014, 87(1041):20140134.

Detappe A, Tsiamas P, Ngwa W, Zygmanski P, Makrigiorgos M, Berbeco R†. “The Effect of Flattening Filter Free Delivery on Endothelial Dose Enhancement With Gold Nanoparticles.”. Med Phys, 2013, 40(3):031706. (featured in the selection best in physics articles from Med Phys. 2013)